Lab research shows effect of prenatal stress on offspring depression

downloadKudos to Dr. Mila Kingsbury, and her lab co-authors Murray Weeks, Nathalie MacKinnon, Jennifer Dykxhoorn, and Ian Colman, for their recent paper in the Journal of the American Academy of Child &  Adolescent Psychiatry (JAACAP) on prenatal stress and offspring depression. This paper used data from the ALSPAC cohort, and included data from more than 10,000 mother-child pairs who had been followed prospectively since the children were in the womb in 1991-92. The paper showed a dose-response relationship between prenatal maternal stress and offspring depression at age 18, even after accounting for maternal depression and anxiety and a host of other covariates.
The paper was accompanied by an editorial in JAACAP by esteemed researcher Andre Sourander, which highlighted the importance of better understanding the influence of early-life stress.
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Michael and Jen’s recent publication on child abuse and suicide

In the article, “Child abuse and the prevalence of suicide attempts among those reporting suicide suicide1ideation,” published recently in Social Psychiatry and Psychiatric Epidemiology, Michael Martin (lead author and APEAL Lab PhD student) and Jen Dykxhoorn (co-author and APEAL Lab MSc alumnus) conclude that most individuals who attempt suicide experience child abuse, and worse health and social functioning. Adopting a life-course perspective to understand trajectories of suicide risk factors may inform prevention and treatment. 

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New publication from APEAL member – Murray Weeks

child1In his new article, entitled “A Developmental pathways linking childhood and adolescent internalizing, externalizing, academic competence, and adolescent depression”, published recently in Journal of Adolescence, Murray examines longitudinal pathways through three domains of adaptation from ages 4-5 to 14-15 (internalizing problems, externalizing problems, and academic competence) towards depressive symptoms at age 16-17.

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Michael Martin publishes again!

Congratulations to PhD student Michael Martin, who published this month in the PLoS ONE journal. In the artimagesicle, entitled “Yield and Efficiency of Mental Health Screening: A Comparison of Screening Protocols at Intake to Prison,” he compares the yield (i.e. newly detected cases) and efficiency (i.e. false positives) of five screening protocols to detect mental illness in prisons against the use of mental health history taking (the prior approach to detecting mental illness).The study found that roughly 40% of prisoners with mental illness were receiving services before incarceration. While screening can identify an additional 20-30% of inmates with previously undetected mental illness, there would be between 2-3 false positives for each newly identified case. 

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Dr. Colman elected as Fellow of APPA

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Congratulations to Dr. Ian Colman, Director of the APEAL Lab, who was recently elected to be a Fellow of the American Psychopathological Association. The American Psychopathological Association (APPA), founded in 1910, is one of the oldest research organizations in North America. The APPA is devoted to the scientific investigation of disordered human behavior, and its biological and psychosocial substrates.

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We are Hiring!

The APEAL Lab is hiring two senior research associates – one research psychologist and one epidemiologist/biostatistician – for an ongoing project on military mental health. The project is in partnership with the Department of National Defence.

The primary responsibility of the Senior Research Associates will be to act as lead researchers for several sub-projects on the epidemiology of mental illness in the Canadian military, using data from the Canadian Forces Mental Health Survey. The Senior Research Associates will work on location at the Department of National Defence, under the supervision of Dr. Colman (uOttawa) and Dr. Mark Zamorski (DND).

The successful candidates will have the opportunity to write first-author papers.

Responsibilities/Activities

  • Independently lead studies of the epidemiology of military health using existing data sources, including:
  1. Design study protocols
  2. Design and implement advanced data analysis plans for projects
  3. Lead discussion of implications of research results with research collaborators
  4. Prepare conference presentations and written manuscripts for peer-review publication
  5. Communicate with research collaborators to facilitate new study initiation and ongoing study completion

How to Apply

If you are interested in either position and meet the requirements listed below, please send an email to Dr. Ian Colman at icolman@uottawa.ca. Please include a cover letter, a CV and the contact details for three referees. We look forward to hearing from you.

Requirements

Education

  • Master’s or doctoral degree in epidemiology, psychology, biostatistics, or equivalent is required.

Experience, skills and abilities

Experience with the following is necessary:

  • 3-5 years experience as an independent researcher
  • analyzing large epidemiological databases and interpreting results of these analyses
  • using statistical software such as SPSS, Stata or SAS, with demonstrated abilities in data linkage, manipulation and statistical analysis.
  • managing epidemiologic and/or statistical research projects from proposal writing to dissemination of results
  • demonstrated leadership skills in collaborating with other researchers
  • authoring peer-reviewed manuscripts

Experience with the following would be an asset:

  • training in psychology or psychiatry
  • research on military mental health
  • psychometric analysis
  • presenting research results at scientific conferences

In addition to the above data analysis skills, the following qualities are essential:

  • must be conscientious in attention to detail
  • must have effective oral and written communication skills in English
  • must be able to work within time constraints
  • must be able and willing to learn new data analysis techniques
  • must be proactive and willing to take initiative, as well as to follow directions

Salary

Salary will be commensurate with experience

Term

12-month contract with possibility of renewal

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APEAL Member Michael Martin Publishes on Diagnostic Errors in Correctional Facilities

Congratulations to PhD student Michael Martin, who published this month in the Journal of Correctional Health Care. His review, entitled “Diagnostic Error in Correctional Mental Health: Prevalence, Causes, and Consequences,” looked in depth at why diagnostic errors occur in jails and what are the implications on subsequent policies. Addressing questions like this help ensure cost-effective mental health services in correctional facilities and can help promote better outcomes for inmates with mental illness. Mental Health in Prisons

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APEAL PhD Student François Thériault Wins Research Day Award

Congratulations to our very own François Thériault who recently won The Robert Spasoff Award, the top prize for best PhD presentation at the annual University of Ottawa School of Epidemiology, Public Health and Preventative Medicine Student Research Day. His presentation was entitled “Mental Health Care as a Socially Learned Behaviour” and he presented preliminary results on help seeking behaviour as it correlates with family and friends’ own help seeking behaviour.

I hope he takes the lab out with his new prize money!Help Seeking Behaviour Among Friends and Family

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Another Publication for the APEAL lab

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APEAL Phd student, Michael Martin, published this week in the journal ‘Public Health’. The article, titled “Food insecurity and mental illness: disproportionate impacts in the context of perceived stress and social isolation“, addresses the co-occurence of food insecurity and mental health in the Canadian Community Health Survey, a nationally representative cross-sectional survey. Mental illness is more common in individuals experiencing food insecurities, and the relationship was strongest in those reporting more stress, weak community belonging and as women—important information when crafting clinical interventions and policy!

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JOIN THE TEAM: THE APEAL LAB IS HIRING! (Position Filled)

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Note: This position has been filled. Thank you to all applicants

The APEAL Lab is currently looking for a biostatistician/analyst to work on a CIHR-funded project on the relationship between depression and mortality. Closing date for applications is November 16, 2015, although the position will remain open until filled. Details are below.

Position Summary

The Research Associate will join Dr. Ian Colman’s research program. Dr. Colman is the Canada Research Chair in Mental Health Epidemiology, and is an Associate Professor in the School of Epidemiology, Public Health & Preventive Medicine. He directs the Applied Psychiatric Epidemiology Across the Life course (APEAL) Lab. The APEAL Lab investigates the epidemiology of common mental illnesses in the general population, with a focus on understanding longitudinal and life-course processes surrounding depression and anxiety.

The primary responsibility of the Research Associate will be to act as the analyst/statistician for a CIHR-funded project on the association between depression and long-term mortality, in collaboration with colleagues at Harvard University and the National Institutes of Health. In addition, the Research Associate may provide support for other projects in the lab, including assisting other staff, MSc and Phd students, and visiting researchers with analytical issues as they arise.

Responsibilities/Activities

  • Perform complex data analysis for a project investigating the relationship between depression and mortality, using data from the Stirling County Study. This will include combining multiple waves of the study in a survival analysis to investigate the primary association between depression and mortality, secular changes over time, moderating and mediating effect of other factors, and heterogeneity in the association between depression and mortality in various subgroups who experience differing symptoms.
  • Write methods and results sections of manuscripts for peer-reviewed publications.
  • Prepare methods and results sections of presentations for research conferences.

Education

  • Master’s or PhD degree in biostatistics, statistics, epidemiology, quantitative psychology, or equivalent is required.

Experience, skills and abilities

Experience with the following is necessary:

  • analyzing epidemiological data and interpreting results of these analyses
  • using and analyzing longitudinal data
  • completing survival analyses
  • using statistical software such as Stata or SAS, with demonstrated abilities in data linkage, manipulation and statistical analysis.
  • creating dissemination-quality data tables and figures using Microsoft Office Word, Excel and Powerpoint
  • managing analytical aspects of an epidemiological research project from proposal writing to dissemination of results

Experience with the following would be an asset:

  • managing large health-related databases
  • writing and editing for research, including grant applications, ethics review applications, manuscripts for peer-reviewed publication
  • presenting research results at scientific conferences
  • performing systematic reviews
  • mental health research
  • psychometric analysis

In addition to the above data analysis skills, the following qualities are essential:

  • must be conscientious in attention to detail
  • must have effective oral and written communication skills in English
  • must be able to work within time constraints
  • must be able and willing to learn new data analysis techniques
  • must be proactive and willing to take initiative, as well as to follow directions

Salary

Salary will be commensurate with experience, within the range of $50,000 – $65,000

Term

12-month contract

Applying

Please send a CV and the names of three references to Ian Colman (icolman@uottawa.ca) before November 16, 2015. The position will remain open until filled.

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